Member Laboratories

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Peter Kuhn and Ray Stevens labs at TSRI

The Kuhn and Stevens labs focus on understanding viruses and their host interactions through protein structure determination on a proteome-wide scale using advanced high-throughput structural genomics technologies, with a view to developing novel therapeutics and diagnostics.

Mike Buchmeier lab at TSRI

Mike Buchmeier's lab is interested in the pathogenesis and control of emerging infections, the structure and function of viral glycoproteins, the mechanisms by which viruses interact with the host during persistent infection, and the way in which viruses contribute to a variety of autoimmune and neurodegenerative diseases.

Ian Wilson lab at TSRI

A major goal of the Wilson lab is to employ X-ray crystallography to understand structure-function relationships and immunologic recognition of pathogens including viruses such as HIV-1, influenza virus and SARS-CoV.

Kurt Wüthrich lab at TSRI

The Wüthrich lab develops and applies state-of-the-art NMR methods to study protein structure, function and folding. As part of structural genomics initiatives, this lab has solved NMR structures of several proteins, including membrane proteins and those of the SARS-CoV.

Jay Nelson lab at OHSU

The long-term goal of Jay Nelson's laboratory is to understand the molecular basis of disease mediated by pathogenic human viruses.

Richard Kuhn and Michael Rossmann at Purdue Univ.

Richard Kuhn's lab interests lie in the study of the molecular mechanisms involved in virus gene expression and the nature of virus-host interactions such as cell receptor binding, fusion, replication and assembly of several families of RNA containing viruses. Michael Rossmann's research interests are in virus structural biology.

Ming Luo lab at UAB

Development of effective and economic therapy of infectious diseases requires thorough understanding of the biology of these infectious agents and innovative approaches to the problems. Ming Luo's laboratory has been involved in X-ray crystallographic analysis of critical proteins and design of novel drugs based on the protein structure.

VISP: Center for Viral Infection Structural Proteomics