|
| Title |
Structure Image |
Structure Detail |
Function |
Interactions |
Biological Role |
|
|
|
| nsp1 |
|
New Fold : PDBID: 2GDT |
Not Known
|
In MHV, nsp1 interacts and/or co-localizes with counterparts of nsp2, 5, 7, 8, 9, 10, 12, 13 and sars9a.
|
Not Known
|
|
|
|
| nsp2 |
|
N/A |
test
|
In MHV, it interacts and/or co-localizes with counterparts of nsp1, 5, 7, 8, 9, 10, 12, 13, and sars9a
|
Not Known
|
|
|
|
| nsp3aUB1 |
|
2GRI |
Not Known
|
Not Known
|
Not Known
|
|
|
|
| nsp3bADRP |
|
Macro-H2A-like fold
|
ADP-Ribose-1'-Phosphate phosphatase
|
ADP-Ribose-1'-Phosphate
|
Terminal step in splicing pathway during synthesis of nested set of sub-genomic mRNAs
|
|
|
|
| nsp3cSUD |
|
N/A |
Putative protease
|
Not Known
|
Not Known
|
|
|
|
| nsp3dPLP2 |
|
PDB ID: 2FE8 Cysteine protease and ubiquitin-like domains. |
Cysteine protease activity.
|
pp1a
|
Proteolytic processing of pp1a/b. Potential de-ubiquitination of SARS proteins.
|
|
|
|
| nsp3eRNABD |
|
N/A |
Not Known
|
Not Known
|
Not Known
|
|
|
|
| nsp3fZn-finger |
|
Quadruple pass TM domain |
Not known
|
Not known
|
Not known
|
|
|
|
| nsp3gY |
|
N/A |
Not Known
|
Not Known
|
Not Known
|
|
|
|
| nsp4 |
|
Helical Transmembrane Protein |
Not determined.
|
Not known
|
Not known
|
|
|
|
| nsp5 |
|
Chymotrypsin-like protease fold. |
Main SARS protease. Cleaves the replicase polyprotein to generate mature non-structural proteins nsp4-nsp16
|
Not known
|
Proteolytic processing of replicase polyprotein.
|
|
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|
| nsp6 |
|
Likely to have seven integral transmembrane helices |
Not known
|
Not known
|
Not known
|
|
|
|
| nsp7 |
|
Helical bundle |
Forms a supercomplex of sixteen subunits with eight copies of itself and eight copies of nsp8
|
Interacts with nsp8 and possibly with RNA polymerase
|
Not clear
|
|
|
|
| nsp8 |
|
New fold. |
Eight copies of interacts with eight copies of nsp7 to form a supercomplex. Possible role of this supercomplex might be to channel RNA through to the polymerase for replication/transcription.
|
interacts with RNA as well as with nsp7.
|
RNA guide during Replication and transcription.
|
|
|
|
| nsp9 |
|
Novel fold related to second domain of SARS-3CL-pro |
RNA binding protein
|
Not characterized.
|
Unknown but possibly involves some form of RNA binding phenomenon.
|
|
|
|
| nsp10 |
|
Novel fold with two zinc fingers. |
RNA binding protein that forms a dodecamer.
|
Interacts with RNA in a sequence non-specific manner.
|
Two possible biological roles have been attributed. (a) It is probably a scaffold for RNA during replication by the SARS polymerase and (b) It is a novel viral transcription factor.
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|
|
|
| nsp11 |
|
11 residue peptide. Most likely unstructured. |
Not known but likely associated with RNA polymerase
|
Possibly interacts with nsp10 and/or nsp12 (The RNA dependent RNA polymerase.
|
Unknown.
|
|
|
|
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|
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| nsp13 |
|
Not Known. |
helicase activity. (Unwinds double stranded regions of genomic and subgenomic RNA during replication.
|
Not characterized.
|
helicase activity during genome replication.
|
|
|
|
| nsp14 |
|
N/A |
Exhibits 3'->5' exonuclease activity. Probably provides proof reading capability to the Replicase machinery.
|
None characterized yet.
|
Exonuclease activity during replication.
|
|
|
|
| nsp15 |
|
Novel Fold: NendoU/XendoU |
Uridylate specific endonuclease
|
Not characterized.
|
Processing and maturation of genomic and subgenomic RNA
|
|
|
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| nsp16 |
|
N/A |
Putative methyltransferase
|
Not identified yet.
|
2'-O ribose cap methylation of viral genomic RNA
|
|
|
|
| sars2 |
|
Helical fusion core, HR1 and HR2 repeats are also helical. |
Recognition of ACE2 receptor and viral entry into infected cells. Major glycoprotein of the virion coat.
|
Interacts with ACE2 receptor on human respiratory cells.
Interacts with Matrix and N proteins. Possibly also with small envelope.
|
Viral entry during pathogenesis.
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|
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| nsp3a |
|
Not Known |
Unclear
|
Unclear
|
Not Known
|
|
|
|
| sars3b |
|
Not Known |
Not Known
|
Not Known
|
Not Known
|
|
|
|
| sars4 |
|
Integral transmembrane protein |
Structural protein of the virion. Induces apoptosis in infected cells.
|
Possibly interacts with spike and/or matrix structural proteins.
|
Viral Structural glycoprotein.
|
|
|
|
| sars5 |
|
Structure not determined yet. |
Adundant viral structural glycoprotein.
|
Interacts with Spike as well as the N (Nucleocapsid) protein.
|
Protein scaffold within the pleomorphic lipidic virion coat.
|
|
|
|
| sars6 |
|
Structure Not known. |
Not known
|
Not known
|
Not known
|
|
|
|
| sars7a |
|
beta sandwich fold. |
Type I integral membrane protein
|
Not determined.
|
Not Known
|
|
|
|
| sars7b |
|
Not known |
Not known
|
Not known
|
Not known
|
|
|
|
| sars8 |
|
Not known |
Not known
|
Not known
|
Not known
|
|
|
|
| sars9a |
|
New fold observed at both the N terminal RNA binding domain as well as the C-terminal oligomerization domains. |
Encases the genomic RNA and packages it into mature virions.
|
Interacts with both genomic as well as sub-genomic RNAs. Further, it interacts with the C-terminus of Matrix (M) protein underneath the viral coat.
|
Genomic RNA packaging and forming higher order structures.
|
|
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| sars9b |
|
Not known |
Not known
|
Not known
|
Not known
|
|
|
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| sars14 |
|
Not known |
Not known
|
Not known
|
Not known
|
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