sars6

Sars6 is a highly hydrophobic membrane-associated peptide that may be a single transmembrane helical protein too. Expression of sars6 in mammalian cells appears to stimulate cellular DNA synthesis. Expression of this protein enhanced the lethality of infection by attenuated MHV, by apparently fostering viral RNA and protein synthesis.

Pewe L, Zhou H, Netland J, Tangudu C, Olivares H, Shi L, Look D, Gallagher T, Perlman S. A severe acute respiratory syndrome-associated coronavirus-specific protein enhances virulence of an attenuated murine coronavirus. J. Virol. 2005 Sep;79(17):11335-42.

Geng H, Liu YM, Chan WS, Lo AW, Au DM, Waye MM, Ho YY. The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: expression and functional characterization. FEBS Lett. 2005 Dec 19;579(30):6763-8. Epub 2005 Nov 21.

Tangudu C, Olivares H, Netland J, Perlman S, Gallagher T. Severe acute respiratory syndrome coronavirus protein 6 accelerates murine coronavirus infections. J Virol. 2007 Feb;81(3):1220-9. Epub 2006 Nov 15.