sars7b

As with many of the other SARS proteins, not much is known about SARS 7b except that it is encoded as a separate open reading frame embedded within the larger Orf 7a. It is also found only in SARS-CoV and is absent even in the closest relatives of SARS (other coronaviruses).

Akerstrom S, Mirazimi A, Tan YJ. Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S. Antiviral Res. 2007 Mar;73(3):219-27.

Pekosz A, Schaecher SR, Diamond MS, Fremont DH, Sims AC, Baric RS. Structure, expression, and intracellular localization of the SARS-CoV accessory proteins 7a and 7b. Adv Exp Med Biol. 2006;581:115-20.

Huang C, Ito N, Tseng CT, Makino S. Severe acute respiratory syndrome coronavirus 7a accessory protein is a viral structural protein. J Virol. 2006 Aug;80(15):7287-94.

Snijder EJ, Bredenbeek PJ, Dobbe JC, Thiel V, Ziebuhr J, Poon LL, Guan Y, Rozanov M, Spaan WJ, Gorbalenya AE. Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage.  J Mol Biol. 2003 Aug 29;331(5):991-1004.